Thesis (B.Sc.D.)--University of Toronto, 1974.
Dental caries, a major public health concern worldwide, is influenced by both environmental and genetic factors. The objective of this study was to identify genetic factors influencing susceptibility to dental caries using mouse strains that show differences in caries by: 1. It was a genome wide association study involving adults, ages , and they examined dental caries against , gene sites in these individuals. They discovered a number of genetic associations and interestingly identified geographic patterns of lesions in the mouth as they related directly to specific genes. This book provides information to the readers starting with the history of oral hygiene manners, and modern oral hygiene practices. It continues with the prevalence and etiology of caries and remedy of caries through natural sources. Etiology of secondary caries in prosthetic restorations and the relationship between orthodontic treatment and caries is addressed. An update of early childhood Author: Zühre Akarslan. Abstract The importance of genetic factors in the genesis of dental caries of both primary and permanent dentitions is well established; however, the degree to which genes contribute to the development of dental caries, and whether these genes differ between primary and permanent dentitions, is largely unknown.
To investigate the risk of predisposition to dental caries among Indian population with the ENAM gene polymorphisms, three different SNPs rs C > T (IleThr), rsG > A (ArgGln) located in exon 10 and rs located in intron 8 were selected and were examined on dental caries children cases and healthy adult controls. On the one hand, the hereditary basis for susceptibility to caries is rather well-founded, and mechanisms for long-term caries prevention, including systemic and topical fluorides, have been generally acknowledged for decades. On the other hand, the genetics of susceptibility to inflammatory periodontal diseases have remained elusive. Dental caries is caused by the acidic environment that results from carbohydrate metabolism when sugars are introduced to the oral microbiome. Enamel and dentin structure, immune response, salivary content and volume, and oral microbiota contribute to the multifactorial and complex etiology of dental caries, but the extent to which susceptibility to caries is under genetic control, and which genes . Genetic aspects of dental disorders (PDF 18P) This paper analyses the past and present applications of quantitative and molecular genetics to dental disorders. Examples are given relating to cranio facial development, oral supporting tissues and dental hard tissues (including defects of enamel and dentine as well as dental caries).
Abstract. This article reviews the literature on genetic aspects of dental caries and provides a framework for the rapidly changing disease model of caries. The scope is genetic aspects of various dental factors affecting dental caries. The PubMed database was searched for articles with keywords ‘caries’, ‘genetics’, ‘taste’, ‘diet’ and ‘twins’. This book explains the genetic basis of a wide range of dental disorders, including dental caries, periodontitis, congenital anomalies, malocclusions, orofacial pain, dental implant failure, and cancer. Such conditions are typically multifactorial or complex, with involvement of more than one gene as well as environmental influences. Dental caries is a bacteria‐mediated disease that is greatly influenced by factors of the host. Host factors influencing dental caries are genetically influenced. Our limited understanding of the genetic influences of the host has impaired our ability for preventing dental caries . The clinical aspects of this topic are covered in a study by Seow noted the influence of DNA methylation on the enamel protein, (amelogenin), produced from genes on the X and Y chromosomes.